Duration
12h Th, 5h Pr, 13h AUTR
Number of credits
Lecturer
Language(s) of instruction
English language
Organisation and examination
Teaching in the first semester, review in January
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
This course provides fundamental knowledge to understand the mechanisms of immune response regulation. The importance of these mechanisms will be highlighted through their implication in vaccinology and antitumoral response.
Learning outcomes of the learning unit
On completion of the theoretical part of the course, students should be able to define and explain the mechanisms governing positive and negative regulation of the immune response. They should have the capacity to analyse and interpret experimental data obtained in vaccinology studies and suggest potential ways to improve a vaccinal response in a given context.
During the seminars, by giving a clear oral presentation, the students should demonstrate that they carried out bibliographic searches and that they are able to analyse and comment results from the literature.
During practical work, the students should be able to follow an experimental procedure and draw conclusions on the experimental data they obtained. The results should be graphically presented and fully discussed in the report.
Prerequisite knowledge and skills
"Immunologie Générale" IMMU0320 (B2)
"Immunopathologie" IMMU0522 (B3).
More precisely, before attending the course, students should know the following immunological bases and concepts:
-origin and function of the innate immune cell types (macrophages, neutrophils, mast cells, eosinophils, dendritic cells and NK).
-origin and function of the adaptive immune cell types (B, CD4+ and CD8+ T cells)
-antigen recognition mechanisms by B and T cells
-activation mechanisms of B and T cells (stimulation and co-stimulation)
-what happens following B and T cell activation and what are the effectors of the immune response
-origin and function of the various T cell subtypes (Th1, Th2, Th17 and Treg)
-the influence of cytokines on the immune response
Planned learning activities and teaching methods
- Theoretical reminder in Immunology (2h) conducted as an anonymous quiz followed by a collective discussion. The quiz and related slides recapitulating the bases of Immunology will be available all year long on eCampus.
- Theoretical lectures (10 hrs) during which the participation of students is warmly welcome. All lessons will be given in English, but students may speek in French if they wish. Each lesson will comprise short activities (quiz, exercises) to stimulate students' active listening and implication during the course. These sessions will help students fixing the important theoretical knowledge and ensure in-depth understanding.
- Seminars are intended to prepare students for the final evaluation (group presentation and final oral exam). These training sessions will include exercises on experimental data analysis and interpretation as well as a paper reading and collective discussion (about a recent vaccinology study.
Following these training sessions, the students will present orally, in small groups, a research article and will take questions (evaluated).
- Practical work : a single session of 5 hrs where students will work in pairs to perform an ELISA experiment. They will generate a brief report containing graphical representation of the data and conclusions.
Mode of delivery (face to face, distance learning, hybrid learning)
Course materials and recommended or required readings
Platform(s) used for course materials:
- eCampus
- MyULiège
Further information:
Recommended reference book (but not mandatory): « Immunologie. Le cours de Janis Kuby » T.J. Kindt, R.A. Goldsby and B.A.
The slides projected during the theoretical lessons will be available on eCampus and/or my.uliege.be.
Technical notes including ELISA experimental procedure and specific questions will be available before the practical session.
Exam(s) in session
Any session
- In-person
oral exam
Written work / report
Out-of-session test(s)
Further information:
First session
Evaluation comprises 3 parts :
- Oral exam : 70%.
- Oral presentation of a research article - group work 'hors session' : 20%.
- Practical work (experimental skills, rigour, active involvement, data presentation and interpretation in the report) -group work 'hors session': 10%.
- Oral exam : 100%
Work placement(s)
Organisational remarks and main changes to the course
-To better match students' workload with the number of credits allocated to the course, IMMU0523 now accounts for 3 credits (instead of 2).
Moreover, the amount of theory has been reduced as the chapter on Immunotherapy will no longer be part of this course. This topic will now be covered within courses in Oncology.
-according to students' wishes, extra training sessions have been scheduled to help students analyse experimental data and interpret vaccinology studies.
Contacts
Pr. Laurence Delacroix,
1 avenue de l'Hôpital - CHU Bat B36+1 - 4000 Liège
Téléphone : 04/366 59 05
Email : ldelacroix@uliege.be
Pr. Nathalie Jacobs
11 avenue de l'Hôpital - CHU Bat B34+5 - 4000 Liège
Téléphone : 04/366 24 20
Email : n.jacobs@uliege.be