Duration
10h Th, 10h Pr
Number of credits
| Master in biomedicine (120 ECTS) | 2 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
The course will define and describe stakes of bioinformatics in XXIst century. Genomic and proteomic databases will be described. Retrieving of sequences in databases will be explained. Some algorithms of exon detection will be exposed. Notions of distance, similarity and homology will be introduced. Dot plots, alignment methods, consensus sequence detection and PCR primer design will be introduced. A chapter will be dedicated to phylogenetics.
Content :
- Introduction and scenario
- Informatic tool
- Cell constituants and bioinformatics
- Dot-plots
- Homology, distance, similarity
- Pair alignment
- Substitution Matrix
- Multiple alignment
- FASTA
- BLAST
- Molecular phylogeny
- Genomics and exon detection
- Structure prediction
- Databases
- Genbank
- Practical lessons
Learning outcomes of the learning unit
Students might be able to use basic bioinformatic softwares available on WWW and to understand mechanisms involved in this softwares. This understanding might allow them to determine limitations of each procedure.
Prerequisite knowledge and skills
Basic knowledge of web.
Statistic and Probability
Planned learning activities and teaching methods
Practical use of bioinformatic web ressources : Genbank, Swissprot, PDB, BLAST, primer3, ...
Mode of delivery (face to face, distance learning, hybrid learning)
Lessons take place during the first master, 2 h/week for 5 weeks.
Recommended or required readings
Syllabus can be obtained on My ULg website. Powerpoint files can be obtained on My ULg website.
Exam(s) in session
Any session
- In-person
oral exam
Additional information:
Oral examination
Work placement(s)
Organisational remarks and main changes to the course
Textbook :
1) Fundamental concepts of bioinformatics, Dan E. Krane & Michael L. Raymer, Benjamin Cummings Editor (2003)
2) Introduction to Bioinformatics, Arthur M. Lesk, Oxford University Press (2002)
Contacts
Olivier Peulen Metastasis Research Laboratory CHU - Tour de Pathologie B23 Te: 04/366.37.92 E-mail: Olivier.Peulen@uliege.be