Duration
35h Th, 36h Pr, 5h SEM
Number of credits
| Bachelor in pharmacy | 5 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the first semester, review in January
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
Introduction to Medicinal Chemistry : scope of medicinal chemistry, presentation of several important reactions in organic synthesis, fundamental principles used in drug design, summary of the rules of the I.U.P.A.C. nomenclature. Systematic Part 1 : drugs used against pathological organisms, anticancer drugs, pesticides.
Learning outcomes of the learning unit
Medicinal chemistry is a science devoted to the design, the synthesis and the understanding of the mode of action of drugs, and more specifically, those obtained by organic synthesis. This science tries to establish a link between the chemical structure of a drug and its biological activity.
The general aims of this course are the following : to familiarize the student with the active components of drugs, their chemical structures, their origin, their design, their evolution, the field of their therapeutic applications, their international nonproprietary names and several examples of trade marks. Some examples of synthesis are provided, the general physicochemical properties are reviewed. The systematic part is introduced by the presentation of the traditional and innovative steps in drug design, by the review of classical synthetic processes and by a summary of the I.U.P.A.C. nomenclature.
At the end of this training, the student must be able to:
- understand how drugs are designed (drug design), prepared (organic synthesis, genetic engineering) and named (i.e. nomenclature of heterocyclic compounds);
- establish relationships between the chemical structure of the drugs and their biological and therapeutic action (structure-activity relationships), as well as the main physico-chemical properties (solubility, acido-basic character, stability, chirality, ...);
- know/recognize the main drugs on the Belgian market by their name (INN, trademark) and their chemical structure and to locate them in their pharmacological class (main therapeutic uses).
Prerequisite knowledge and skills
Appropriate knowledge of inorganic and organic chemistry, basic knowledge of physiology.
Planned learning activities and teaching methods
Seminars (5 h): repetitions on the important concepts of the theoretical course.
Practical work (36 h): chemical synthesis of drugs ; characterization of the main organic functions and general physicochemical properties of the synthesized compounds.
Place : laboratory for the students, +4 floor, tour 4, Bât. B36.
Mode of delivery (face to face, distance learning, hybrid learning)
The lessons (2 h) are usually given twice weekly during the first quadrimester.
Seminars (5 hours) are provided during which repetitions of important concepts of the theoretical course are discussed from a practical point of view (exercises on solubility, nomenclature, organic synthesis reactions, ...).
Practical works (36 hours) are usually organized in two sessions (4 hours) per week during the first quadrimester.
Recommended or required readings
Written notes upgraded each year are distributed to the students.
Exam(s) in session
Any session
- In-person
written exam ( multiple-choice questionnaire, open-ended questions )
Other : Note for practical work
Additional information:
Written exam in january (first session).
Written exam in august-september (second session).
The practical exercices account for 20% of the overall score (4 points out of 20).
For students in a position of second session and with a score above or equal to 8/20, a dispensational interrogation can be held in April allowing to be exempted from half the matter of the first quadrimester (introduction part) for the exam of second session in August-September (exemption with a score> or = 13/20).
Work placement(s)
Organisational remarks and main changes to the course
Contacts
Professeur Bernard PIROTTE Laboratoire de Chimie Pharmaceutique Quartier Hôpital, 15, Avenue Hippocrate, B-4000 Liège C.H.U. - tour 4 - niveau + 5 (Bât. B36) tel : 04 366 43 65 - fax : 04 366 43 62 e-mail: B.Pirotte@uliege.be Secrétariat : Mme Annabelle HAMANDE (tel : 04 366 43 61)