PHAR0331-3

Duration

22h Th, 36h Pr, 5h SEM

Number of credits

	Bachelor in pharmacy	5 crédits

Lecturer

Michel Frederich

Language(s) of instruction

French language

Organisation and examination

Teaching in the first semester, review in January

Schedule

Schedule online

Units courses prerequisite and corequisite

Prerequisite or corequisite units are presented within each program

Learning unit contents

Pharmacognosy (partim 1) is mainly focused on phytochemistry: presntation of various kinds of primary (carbohydrates, lipids, proteins ) and mainly secondary metabolites (phenylpropanoids: lignans, flavonoids, coumarins.., terpenoids and steroids, alkaloids...)

Part 1 of the course will mainly focus on phytochemistry: presentation of the different classes of primary and especially specialized (secondary) metabolites involved either in the therapeutic activity of plants or natural raw materials (active principles), their toxicity (toxic principles), their characterization (tracer principles), or their valorization in pharmaceutics (excipients) or in the agri-food sector (nutritional values).

Knowledge of chemical structures (based on their biosynthetic origin) is very important to evaluate their solubility, stability, and thus better understand the extraction processes (different solvents) and specific control methods (plants, extracts, essential oils). In many cases, a structure-activity relationship is established.

TABLE OF CONTENTS:

Chapter 1: Introduction and specialized metabolism. Chapter 2: Review of carbohydrates / lipids / proteins.Chapter 3: Pharmacognosy analysis methods. Chapter 4: Overview of phytochemical classes of interest in pharmacognosy (Carbohydrates/lipids/proteins; shikimates - C6C1 and phenylpropanoids, coumarins, lignans -; polyacetates; terpenes; stilbenes; flavonoids; gallic tannins; condensed tannins; sulfur glycosides; cyanogenic glycosides; alkaloids). Chapter 5: Polysaccharides of pharmaceutical interest. Chapter 6: Flavonoids. Chapter 7: Tannins. Chapter 8: Other phytochemical classes with therapeutic properties: polyols, waxes, specific proteins, cyanogenic glycosides, sulfur glycosides, salicylates, furanocoumarins, iridoids, anthraquinones, cardiotonic glycosides, saponins, essential oils. Chapter 9: Alkaloids of pharmaceutical interest: anticancer, analgesics, para and orthosympathetic agonists and antagonists, others. Chapter 10: Non-alkaloid anticancer and antiparasitic metabolites (artemisinin, podophyllotoxin, other polyacetates). Chapter 11: Vitamins

Learning outcomes of the learning unit

The Pharmacognosie partim I course aims to provide resources for the future pharmacist in the following Key Learning Outcomes (KLO): Pharmaceutical Expertise (1), Preparation of medicines (2), Health Care Consulting (3), Management of work (5), Meaning of responsibility (6), Quality management (7).

The Pharmacognosy course Partim I aims to provide resources to future pharmacists in the following key learning outcomes (KLO) of the bachelor's degree: Pharmaceutical expertise (1), Drug preparation (2), Health care advice (3), Work management (5), Sense of responsibility (6), Quality management (7).

The course will specifically aim to ensure the training of future pharmacists regarding the following points:

Knowing the major phytochemical classes found in medicinal plants (chemistry, physicochemical properties, stability, biosynthetic origin, specific pharmacological or toxicological properties). This knowledge should be applicable in subsequent courses related to drug analysis and manufacturing.
Understanding the impact of certain (primary and) secondary metabolites on health (plant fibers, fatty acids, etc.).
Knowing the specialized metabolites used as active ingredients or pharmaceutical excipients.
Knowing the specific quality control methods used in Pharmacognosy (European Pharmacopoeia 11.0).

Prerequisite knowledge and skills

Organic chemistry

Analytical chemistry

Biochemistry,

Botany

Planned learning activities and teaching methods

Practicals and seminars:
Extraction , identification and assay of active principles from medicinal plants (monographs of European Pharmacopoeia).
Attendance during practical work is mandatory.
LOCATION: Practicals: Laboratory of chemistry ( 4th floor) of the Pharmaceutical Institute (B36).
Seminars: According to timetable.

The theoretical course will be delivered in person, but some podcasted courses will be possible as well as flipped classrooms.

Practical work and seminars are also organized. These will be assessed during the semester (reports and quizzes) and by a final theoretical exam.

Practical work:

Extraction, identification, and quantification of active ingredients of natural origin from plant materials (phytochemistry monographs of the European Pharmacopoeia).

Attendance at practical work is mandatory. An attendance rate below 80% may result in ineligibility for the exam. In case of justified absence leading to an attendance rate below 80%, the teachers reserve the right to take any measures they deem necessary for the student to make up the missed session(s).

Furthermore, in case of unjustified absence from a practical session, it will be penalized with a zero grade, which will be taken into account in the calculation of the average.

Absence justifications must be submitted to the scientific staff and the educational office no later than three working days after the absence (possibly by email), except in cases of duly justified force majeure.

Seminars:

Problems.

Location:

Practical work: Large chemistry laboratory on the 4th floor of B36 and laboratory on the 3rd floor of B36.
Seminars: According to schedule.

Mode of delivery (face to face, distance learning, hybrid learning)

Blended learning

Additional information:

From September to December.
Ground floor of Pharmaceutical Institute (Building B 36)

Blended learning

Additional information:

The course will be given mainly face-to-face, with some remote activities.

Additional information:

From September to December.

Assessment methods and criteria

Exam(s) in session

Any session

- In-person

written exam ( multiple-choice questionnaire, open-ended questions )

Out-of-session test(s)

Other : Practicals

Additional information:

Written examination about definite matter. Practicals: 10% of total.

Exam(s) in session

Any session

- In-person

written exam ( multiple-choice questionnaire, open-ended questions )

Written work / report

Out-of-session test(s)

Further information:

Other : Practicals

Additional information:

Written examination about definite matter. Practicals and practical exam: 20% of total.

Work placement(s)

Possibility of internship. Student instructor: possibilities are offered for students interested in teaching pharmacognosy. The tasks consist of supervising practical work. Research: outside of class and examination periods (from the end of block 2 of the Bachelor in Pharmaceutical Sciences), motivated students can do an internship in the laboratory (student-researchers). At the end of the course, a doctorate is possible in the service.

Organizational remarks

All informations about the course will be givent through ecampus.

Contacts

Pr Michel FREDERICH Tel: +32 4 3664331 Fax: +32 4 3664332 e-mail: M.Frederich@ulg.ac.be

Secretary's office: Mrs Bérangère RENAVILLE Tel: 043664331
Scientific Assistants: Ollivier BONNET (Tél:043664336) and Allison LEDOUX (Tél:043664338)

Pr Michel FREDERICH
Tel: +32 4 3664331
Fax: +32 4 3664332
e-mail: M.Frederich@ulg.ac.be

Secretary's office: Mrs Bérangère RENAVILLE Tel: 043664331

Scientific Assistants:
Ollivier BONNET (Tél:043664336) and Allison LEDOUX (Tél:043664338)

Pharmacognosy (Part I)