Duration
57h Th, 18h Pr, 9h AUTR
Number of credits
| Master in bioengineering: chemistry and bio-industries, professional focus | 8 crédits |
Lecturer
Frank Delvigne, Patrick Fickers, Philippe Jacques, Marc Ongena, Jean-Claude Twizere
Coordinator
Language(s) of instruction
English language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
This course focus on theoretical and practical aspects on technologies related to the production aof compounds of biotechnological interest (biomass, proteins, metabolites) for agro-food, chemical and biopharmaceutical industries. The course details the different technologies of bioreactor culture, molecular techniques leading to the development of "cell factory" as well as cell-environment interactions.
Learning outcomes of the learning unit
At the end of this multidisciplinary module, students will be able to integrate the different aspects of the development, implementation, optimization and control of a process of production of a compound of interest in bioreactor. The course also includes dimensioning part (calculation of oxygen transfer capacity, dynamics of microbial growth and production of metabolites, ...) and on the construction of dynamic models of bioprocesses (resolution of first-order differential equations under MatLab).
Prerequisite knowledge and skills
BIOL2010-1 : Biologie cellulaire
BIOL2013-2 : Microbiologie générale - Patrim 1
BIOL2013-3 : Microbiologie générale - Partim 2
BIOL2015-3 : Biologie moléculaire
BIAA0003-1 : Génie industriel alimentaire et ingénierie agro-alimentaire - 1ère partie
MATH2016-1 : mathématique générale et modélisation des systèmes dynamiques
Planned learning activities and teaching methods
- Bioreactor engineering (F. Delvigne, Th)
- Metabolic engineering (P. Fickers, P. Jacques, Th)
- Microbial interaction (M. Ongena, Th)
- Animal cell culture (JC Twizere , Th)
- Purification (filtration, centrifugation, chromatography...) (P. Fickers,Th)
- Exercices (F. Delvigne, P. Fickers, P. Jacques )
- Lab (P. Fickers, P. Jacques, M. Ongena, F. Delvigne)
- Numerical simulation (F. Delvigne, exercices)
Beside ex-cathedra courses, this module includes practical lab work, exercises (simulation on MatLab), seminars (industrials, academics or research centers) and company visits Active. In this course, a pedagogical approach "learning by doing" will also be favored..
Mode of delivery (face to face, distance learning, hybrid learning)
Face-to-face course
Further information:
Lectures
Lab training
Exercices (numerical simulation using MatLab),
Seminars
In this course, a pedagogical approach "learning by doing" will also be favored.
Course materials and recommended or required readings
Exam(s) in session
Any session
- In-person
written exam
Written work / report
Further information:
Individual Report
Writen exam
Work placement(s)
Organisational remarks and main changes to the course
For security reasons, access to the laboratory is only permitted to officially registered students. Each student must take care not to forget their laboratory coat, their safety glasses and the practical workbook which will be provided at the first session (one per group). No 'rescue' lab coat will be provided to those who are distracted. The laboratory is a potentially dangerous place; drinking, eating and smoking are strictly prohibited. It is essential to wear closed shoes, pants and tie up long hair. The laboratory groups will be defined before the first session and cannot be modified afterwards. Generally speaking, the instructions relating to safety in the chemistry laboratory must be respected (vade mecum available at TERRA)
Contacts
Prof. Patrick Fickers
Microbial Processes and Interactions (MiPI)
Ph: 081 622 311 (direct), 081 622 305 (secretariat)
pfickers@uliege.be
Association of one or more MOOCs
Items online
Fickers_2022_Centrifugation_Filtration
Lecture on centrifugation and filtration
Fickers_2022_Metabolic engineering
Lecture on Metabolic Engineering
Interactome networks to understand genotype-phenotype relationships
The slides contain key slides to explain genotype - phenotype relationships, based on the understanding genotype-phenotype relationships. We will focus on protein-protein interactions technologies and give pratical examples.