Duration
20h Th, 40h Pr
Number of credits
| Bachelor in biology | 4 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
In its first part, this course highlights the importance of equilibria in biochemistry, whereas the second part is an introduction of some fundamental aspects in enzyme kinetics. The first part is organized as follows: 1) Chemical equilibria; 2) Acid-base equilibria; 3) Complexation equilibria. As for the second part: 1. General properties of enzymes; 2. Steady-state kinetics; 3. Enzyme inhibition. More in depth analysis is covered in the Master course entitled "Enzymology".
Learning outcomes of the learning unit
The aim of this course is to familiarize students with equilibria in biochemistry and also with some fundamental aspects of enzymology.
Prerequisite knowledge and skills
Fundamentals of mathematics, chemistry and biochemistry.
Planned learning activities and teaching methods
The first part of the course describes some important aspects relating to equilibria in biochemistry. The second part consists in an introduction to enzyme kinetics. Witten exercises and practical courses are full part of the teaching.
Mode of delivery (face to face, distance learning, hybrid learning)
Face-to-face course
Further information:
Most lectures are given using the blackboard and white chalk. Problem tutorials are organized in relation with some chapters. Finally, 40 h of practical course are dedicated to enzyme kinetics.
Attendance at the introductory session for the practical work is mandatory and is a prerequisite for participation in the practical sessions.
Course materials and recommended or required readings
Lecture notes are distributed as the course progresses.
Some references:
N.C. Price, R.A. Dwek, R.G. Ratcliffe and M.R. Wormald, Principles and Problems in Physical Chemistry for Biochemists, Third Edition, Oxford University Press, 2001.
K.E. van Holde, W. C. Johnson, P.S. Ho, Principles of Physical Biochemistry, Prentice Hall, 1998.
A. Cornish-Bowden, M. Jamin, V. Saks: Cinétique enzymatique, Grenoble Sciences/EDP Sciences, 2005.
A.R. Fersht, Structure and mechanism in protein science, W.H. Freeman and Co, 1999.
Exam(s) in session
Any session
- In-person
written exam ( open-ended questions )
Written work / report
Further information:
Written exam + practical courses
Active in-person participation in the practical sessions is also mandatory. In accordance with Article 61 of the General Study and Evaluation Regulations (academic year 2024-2025), a student will not be allowed to take the assessments for this course unit or be awarded the corresponding credits if this requirement is not met.
Work placement(s)
Non applicable
Organisational remarks and main changes to the course
Lectures will be organized according to the schedule known by the students. The professor will inform the students in advance of any possible modification to this
Contacts
André Matagne, PhD, Professor, Enzymology and Protein Folding, Centre for Protein Engineering, InBioS RU, Life Science Department, Institut de Chimie B6a (room 1/10a), Allée de la Chimie, 3, University of Liège, B4000 Liège (Sart-Tilman), Tel.: +32 (0)4 3663419, Email: amatagne@uliege.be (to be preferred)