Duration
40h Th, 10h AUTR
Number of credits
| Master in biomedicine (120 ECTS) | 5 crédits |
Lecturer
Alain Chariot, Pierre Francotte, Christian Grandfils, Géraldine Piel
Language(s) of instruction
English language
Organisation and examination
Teaching in the first semester, review in January
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
The course is composed of 3 interconnected modules:
Medical and pharmaceutical applications in molecular biology - We will describe at the molecular level a variety of signaling pathways. We will also describe how these signaling pathways are deregulated in clinical cases of solid tumors of inflammatory disorders. We will identify several therapeutic targets of these diseases and will describe ongoing clinical trials in which new proteins are targeted. We will describe at the molecular level the key mechanisms by which any cancerous or inflammatory diseases are progressing. The goal would be for any student to have a good knowledge of theses molecular mechanisms.
Methodology of Pharmaceutical Research - This module browses the different approaches explored to develop new drugs. Students are expected to become familiar with the different problems encountered during the design of new drugs.
Introduction to the Pharmaceutical Technology - After a brief history and some definitions, the modules is focused on the administration routes of medicines, the future of the medicine in the body (notions of bioavailability, bioequivalence, pharmacokinetics), the pharmaceutical forms and the modulation of the in vivo future of a medicine. The students may thus understand the strategies followed to control the release kinetics of the active principle, to improve the bioavailability, to control the distribution of the active principle in the body - the vectors, to control the site and the moment of liberation of the active principle.
Learning outcomes of the learning unit
Medical and pharmaceutical applications in molecular biology - To understand at the molecular level a variety of inflammatory disorders and malignant diseases by concentrating on intestinal cancers and on the Crohn disease for example.
Identification of key cellular and molecular actors involved in the development of these human diseases.
Get a better undertanding of the mechanisms by which a variety of drugs currently used in the clinics or in ongoing clinical trials are acting
Identification of new therapeutic targets based on the most recent findings published in the litterature
Methodology of Pharmaceutical Research - At the end of the cursus, students are expected to understand the different concepts used to discover and develop new drugs.
Introduction to the Pharmaceutical Technology - The objective of this course is to give a global outline of the Pharmaceutical Technology, to present the possibilities that offers this discipline to modify the pharmacokinetic of an active substance, describe the current tendencies in the point of view of the biopharmacy as from the point of view of the technology.
Prerequisite knowledge and skills
Medical and pharmaceutical applications in molecular biology - A basic knowledge of the tools used in molecular biology is required (PCR, Southern blots, restriction enzymes, etc...) even if I will quickly describe again the main techiques used in the laboratories at the first course.
A basic knowledge of the DNA, RNA and protein structures is required (gene transcription, the genetic code, ..etc.).
Methodology of Pharmaceutical Research - Basic notions in chemistry, pharmacology and in physio(patho)logy
Planned learning activities and teaching methods
Medical and pharmaceutical applications in molecular biology - 5 courses will be given and all slides are already available. Ongoing research projects will also be described in order for the students to get familiar with the research community and to have access to the latest findings in our field of research. All students will have the opportunity to visit the laboratories at the GIGA. They will also have the opportunity to talk with PhD students and post-doctoral researchers.
Methodology of Pharmaceutical Research - Courses will be given face to face and slides will be available.
Introduction to the Pharmaceutical Technology - Courses will be given face to face and slides will be available
Mode of delivery (face to face, distance learning, hybrid learning)
Blended learning
Additional information:
Medical and pharmaceutical applications in molecular biology - En présentiel.
Methodology of Pharmaceutical Research - in classroom (a part could be given online).
Introduction to the Pharmaceutical Technology - In classroom
Recommended or required readings
Medical and pharmaceutical applications in molecular biology - Recently published research articles will be available to the students as well as all slides. Methodology of Pharmaceutical Research - A selection of reference books will be available through the online platform. Biocompatibility of implants and biomaterials - Book references are given at the first lecture Introduction to the Pharmaceutical Technology - Slides are available via ecampus Medical and pharmaceutical applications in molecular biology - Slides are available via ecampus
Exam(s) in session
Any session
- In-person
oral exam
Additional information:
Oral examination will be achieved in front of the three lecturers.
Work placement(s)
Medical and pharmaceutical applications in molecular biology - Any student who would be interested to start a career in science will have the opportunity to come in the laboratory anytime.
Organisational remarks and main changes to the course
Opening of the course with a minimum of 3 registrants
Contacts
Alain.Chariot@uliege.be - Pierre.Francotte@uliege.be - Geraldine.Piel@uliege.be