Duration
Theory : 25h Th
Practical work for pharmacy : 6h Pr
Number of credits
| Bachelor in pharmacy | 4 crédits |
Lecturer
Theory : Didier Cataldo
Practical work for pharmacy : Didier Cataldo
Language(s) of instruction
French language
Organisation and examination
Teaching in the first semester, review in January
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
Teacher : D. Cataldo, Professor
The definition of General Physiology is the study of the properties which are common to all cells and living animals (and plants).
Among these common properties, there are the major metabolic pathways already studied during the General Biochemistry lectures. The ability for a cell to keep constant its internal environment despite variations of the external environment is an other very important property common to all cells and living beings. This constance is favorable and required for optimal biochemical reactions. This property so-called homeostasis is also studied by General Physiology.
Homeostasis includes the possibility for a cell to detect a modification in its environment or an external information and to respond it appropriately. However all cells or all cells in a living organism are not identical. They are able to provide particular function and thus, have specific and different internal environment given their function. In consequence, cells have to dialog with each other and the integration of all these informations at the cellular level is also the purpose of General Physiology.
Conceptually, the regulation of internal environment involves: 1) detection of a modification by various sensor systems of the cell or of the body, 2) the transmission of an information from the sensor to a central integrator and 3) an appropriate response of this integrative centre. This response could be either direct or performed by an effector after a new step of transmission which carries now the response information. Such an approach emphasizes the importance of physical borders between internal and external fluid in a cell or in a living organism. Thus, it is at the cell membrane that most of the mechanisms involved in sensing (receptors) and in response (secretion, ion fluxes, ...) are present.
The general objectives of these lectures are:
1) To understand the need to maintain a constant internal environment in order to keep the good conditions for biochemical reactions. Moreover, the internal environment could be a little bit different in various cell compartments (lysosomes, nucleus, ...).
2) To understand how molecules move across a compartment or through a biological membrane.
3) To understand the impact on the osmotic pressure of the diffusion of molecules.
4) To understand the phenomenon of osmosis in cell in which the molecule concentration in cytoplasm is higher than in the external fluid. This situation requires to make the cell membrane impermeant to sodium.
5) To understand the consequences on the membrane potential of the inhomogenous distribution of various ionic species on both sides of a biological membrane.
6) To understand how living beings have used the existence of this membrane potential to signalize, particularly in the nervous system.
Theory
Teacher : D. Cataldo, Professor
The definition of General Physiology is the study of the properties which are common to all cells and living animals (and plants).
Among these common properties, there are the major metabolic pathways already studied during the General Biochemistry lectures. The ability for a cell to keep constant its internal environment despite variations of the external environment is an other very important property common to all cells and living beings. This constance is favorable and required for optimal biochemical reactions. This property so-called homeostasis is also studied by General Physiology.
Homeostasis includes the possibility for a cell to detect a modification in its environment or an external information and to respond it appropriately. However all cells or all cells in a living organism are not identical. They are able to provide particular function and thus, have specific and different internal environment given their function. In consequence, cells have to dialog with each other and the integration of all these informations at the cellular level is also the purpose of General Physiology.
Conceptually, the regulation of internal environment involves: 1) detection of a modification by various sensor systems of the cell or of the body, 2) the transmission of an information from the sensor to a central integrator and 3) an appropriate response of this integrative centre. This response could be either direct or performed by an effector after a new step of transmission which carries now the response information. Such an approach emphasizes the importance of physical borders between internal and external fluid in a cell or in a living organism. Thus, it is at the cell membrane that most of the mechanisms involved in sensing (receptors) and in response (secretion, ion fluxes, ...) are present.
The general objectives of these lectures are:
1) To understand the need to maintain a constant internal environment in order to keep the good conditions for biochemical reactions. Moreover, the internal environment could be a little bit different in various cell compartments (lysosomes, nucleus, ...).
2) To understand how molecules move across a compartment or through a biological membrane.
3) To understand the impact on the osmotic pressure of the diffusion of molecules.
4) To understand the phenomenon of osmosis in cell in which the molecule concentration in cytoplasm is higher than in the external fluid. This situation requires to make the cell membrane impermeant to sodium.
5) To understand the consequences on the membrane potential of the inhomogenous distribution of various ionic species on both sides of a biological membrane.
6) To understand how living beings have used the existence of this membrane potential to signalize, particularly in the nervous system.
Practical work for pharmacy
Teacher : D. Cataldo, Professor
The definition of General Physiology is the study of the properties which are common to all cells and living animals (and plants).
Among these common properties, there are the major metabolic pathways already studied during the General Biochemistry lectures. The ability for a cell to keep constant its internal environment despite variations of the external environment is an other very important property common to all cells and living beings. This constance is favorable and required for optimal biochemical reactions. This property so-called homeostasis is also studied by General Physiology.
Homeostasis includes the possibility for a cell to detect a modification in its environment or an external information and to respond it appropriately. However all cells or all cells in a living organism are not identical. They are able to provide particular function and thus, have specific and different internal environment given their function. In consequence, cells have to dialog with each other and the integration of all these informations at the cellular level is also the purpose of General Physiology.
Conceptually, the regulation of internal environment involves: 1) detection of a modification by various sensor systems of the cell or of the body, 2) the transmission of an information from the sensor to a central integrator and 3) an appropriate response of this integrative centre. This response could be either direct or performed by an effector after a new step of transmission which carries now the response information. Such an approach emphasizes the importance of physical borders between internal and external fluid in a cell or in a living organism. Thus, it is at the cell membrane that most of the mechanisms involved in sensing (receptors) and in response (secretion, ion fluxes, ...) are present.
The general objectives of these lectures are:
1) To understand the need to maintain a constant internal environment in order to keep the good conditions for biochemical reactions. Moreover, the internal environment could be a little bit different in various cell compartments (lysosomes, nucleus, ...).
2) To understand how molecules move across a compartment or through a biological membrane.
3) To understand the impact on the osmotic pressure of the diffusion of molecules.
4) To understand the phenomenon of osmosis in cell in which the molecule concentration in cytoplasm is higher than in the external fluid. This situation requires to make the cell membrane impermeant to sodium.
5) To understand the consequences on the membrane potential of the inhomogenous distribution of various ionic species on both sides of a biological membrane.
6) To understand how living beings have used the existence of this membrane potential to signalize, particularly in the nervous system.
Learning outcomes of the learning unit
- To be able to explain how the cell structure is maintained meanwhile this cell assume a particular function (cell membrane permeability, cellular volume regulation, muscle contraction, transmission of nervous information ...).
- To be able to give a molecular explanation to the phenomenon characterizing the living organisms.
- To be able to give a global explanation about the complexity of the coordination system regulating the interactions between the various systems of the organism.
- To be able to describe the relationships between specific metabolic pathways and the environmental properties.
- To be able to use all these informations to start in good conditions the study of Human Physiology.
Theory
- To be able to explain how the cell structure is maintained meanwhile this cell assume a particular function (cell membrane permeability, cellular volume regulation, muscle contraction, transmission of nervous information ...).
- To be able to give a molecular explanation to the phenomenon characterizing the living organisms.
- To be able to give a global explanation about the complexity of the coordination system regulating the interactions between the various systems of the organism.
- To be able to describe the relationships between specific metabolic pathways and the environmental properties.
- To be able to use all these informations to start in good conditions the study of Human Physiology.
Practical work for pharmacy
- To be able to explain how the cell structure is maintained meanwhile this cell assume a particular function (cell membrane permeability, cellular volume regulation, muscle contraction, transmission of nervous information ...).
- To be able to give a molecular explanation to the phenomenon characterizing the living organisms.
- To be able to give a global explanation about the complexity of the coordination system regulating the interactions between the various systems of the organism.
- To be able to describe the relationships between specific metabolic pathways and the environmental properties.
- To be able to use all these informations to start in good conditions the study of Human Physiology.
Prerequisite knowledge and skills
Upstream : Biology, Chemistry, Physics and General Biochemistry.
This course constitutes an introduction to Human Biochemistry, Human Physiology and Pathology.
Theory
Upstream : Biology, Chemistry, Physics and General Biochemistry.
This course constitutes an introduction to Human Biochemistry, Human Physiology and Pathology.
Practical work for pharmacy
Upstream : Biology, Chemistry, Physics and General Biochemistry.
This course constitutes an introduction to Human Biochemistry, Human Physiology and Pathology.
Planned learning activities and teaching methods
Lectures will be ex cathedra or on-line. Two sessions of laboratory works are organized in all sections as on-line or presential activities. The first session is devoted to the recording of action potentials in various circumstances and the second session is focused on the study of a functional neuromuscular junction. At the end of each session, groups of students must submit a report that will be evaluated.
Theory
Lectures will be ex cathedra. Two sessions of laboratory works are organized in all sections. The first session is devoted to the recording of action potentials in various circumstances and the second session is focused on the study of a functional neuromuscular junction.At the end of each session, groups of students must submit a report that will be evaluated.
Practical work for pharmacy
Lectures will be ex cathedra. Two sessions of laboratory works are organized in all sections. The first session is devoted to the recording of action potentials in various circumstances and the second session is focused on the study of a functional neuromuscular junction.At the end of each session, groups of students must submit a report that will be evaluated.
Mode of delivery (face to face, distance learning, hybrid learning)
I. General introduction, homeostasis.
1. Homeostasis of internal environment.
II. Physico-chemical basis of internal regulation.
2. Diffusion and cell membrane permeability.
3. Osmotic pressure and water displacements.
III. Ionic channels and excitable membranes.
4. Ion channels.
5. Electrical consequences of ionic gradients.
6. Passive electrical properties of cell membranes.
7. Action potential onset and propagation.
8. Ionic channels diversity.
IV. Solutes transports.
9. Electrochemical potential energy
10. Passive transport of solutes
11. Active transport.
V. Message Transduction.
12. Ligand-receptor couple and second messengers.
Theory
I. General introduction, homeostasis.
1. Homeostasis of internal environment.
II. Physico-chemical basis of internal regulation.
2. Diffusion and cell membrane permeability.
3. Osmotic pressure and water displacements.
III. Ionic channels and excitable membranes.
4. Ion channels.
5. Electrical consequences of ionic gradients.
6. Passive electrical properties of cell membranes.
7. Action potential onset and propagation.
8. Ionic channels diversity.
IV. Solutes transports.
9. Electrochemical potential energy
10. Passive transport of solutes
11. Active transport.
V. Message Transduction.
12. Ligand-receptor couple and second messengers.
Practical work for pharmacy
I. General introduction, homeostasis.
1. Homeostasis of internal environment.
II. Physico-chemical basis of internal regulation.
2. Diffusion and cell membrane permeability.
3. Osmotic pressure and water displacements.
III. Ionic channels and excitable membranes.
4. Ion channels.
5. Electrical consequences of ionic gradients.
6. Passive electrical properties of cell membranes.
7. Action potential onset and propagation.
8. Ionic channels diversity.
IV. Solutes transports.
9. Electrochemical potential energy
10. Passive transport of solutes
11. Active transport.
V. Message Transduction.
12. Ligand-receptor couple and second messengers.
Recommended or required readings
Syllabus is available electronically (files available on eCampus). All the files used for lectures (illustrations and resumes) will also be available just before each lectures. All the recent books dedicated to General Physiology or Cellular Physiology can be used but are not mandatory.
Theory
Syllabus is available electronically (files available on eCampus). All the files used for lectures (illustrations and resumes) will also be available just before each lectures. All the recent books dedicated to General Physiology or Cellular Physiology can be used but are not mandatory.
Practical work for pharmacy
Syllabus is available electronically (files available on eCampus). All the files used for lectures (illustrations and resumes) will also be available just before each lectures. All the recent books dedicated to General Physiology or Cellular Physiology can be used but are not mandatory.
Assessment methods and criteria
Exam(s) in session
Any session
- In-person
written exam ( multiple-choice questionnaire, open-ended questions )
Additional information:
Any session :
- In-person
written exam ( multiple-choice questionnaire, open-ended questions )
- Remote
written exam ( multiple-choice questionnaire, open-ended questions )
- If evaluation in "hybrid"
preferred in-person
Additional information:
The exam will consist of multiple choices questions, questions with long and short answers. Questions will also comprise specific items concerning the practical works.
Examinations will take place as on-line or presential activities.
Theory
The exam will consist of multiple choices questions, questions with long and short answers. Questions will also comprise specific items concerning the practical works.
Practical work for pharmacy
Any session :
- In-person
written exam ( multiple-choice questionnaire, open-ended questions )
- Remote
written exam ( multiple-choice questionnaire, open-ended questions )
- If evaluation in "hybrid"
preferred in-person
Additional information:
The exam will consist of multiple choices questions, questions with long and short answers. Questions will also comprise specific items concerning the practical works.
Work placement(s)
Organizational remarks
All related materials including slides and syllabus are available on the eCampus platform dedicated to this course. The attendance is mandatory for at least 60% of sessions regarding practical works. In 2020-2021, this attendance is not mandatory.
Theory
All related materials including slides and syllabus are available on the eCampus platform dedicated to this course. The attendance is mandatory for at least 60% of sessions regarding practical works.
Practical work for pharmacy
All related materials including slides and syllabus are available on the eCampus platform dedicated to this course. The attendance is mandatory for at least 60% of sessions regarding practical works.
Contacts
Adresse ULiege :
Professeur Didier Cataldo
Tour de Pathologie (B23) 3ème étage
Tél : 04/366.25.21
Christel Péqueux
Chef de travaux
Tél. Ulg 32 4 366 22 17
Couriel : C.Pequeux@uliege.be
Laurence Delacroix
Chef de travaux
Tél. Ulg 32 4 366 25 02
Couriel : ldelacroix@uliege.be
Jessical Thys
Secrétaire
Tél ULg : 32 4 366 59 50
Couriel : jessica.thys@uliege.be
Theory
Adresse ULg :
Professeur Didier Cataldo
Tour de Pathologie (B23) 3ème étage
Tél : 04/366.25.21
Christel Péqueux
Chef de travaux
Tél. Ulg 32 4 366 22 17
Couriel : C.Pequeux@uliege.be
Laurence Delacroix
Chef de travaux
Tél. Ulg 32 4 366 25 02
Couriel : ldelacroix@uliege.be
Jessical Thys
Secrétaire
Tél ULg : 32 4 366 59 50
Couriel : jessica.thys@uliege.be
Practical work for pharmacy
Adresse ULg :
Professeur Didier Cataldo
Tour de Pathologie (B23) 3ème étage
Tél : 04/366.25.21
Christel Péqueux
Chef de travaux
Tél. Ulg 32 4 366 22 17
Couriel : C.Pequeux@uliege.be
Laurence Delacroix
Chef de travaux
Tél. Ulg 32 4 366 25 02
Couriel : ldelacroix@uliege.be
Jessical Thys
Secrétaire
Tél ULg : 32 4 366 59 50
Couriel : jessica.thys@uliege.be