Duration
35h Th, 15h AUTR
Number of credits
| Master in biomedicine (120 ECTS) | 5 crédits |
Lecturer
Language(s) of instruction
English language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
Partim Charlier
Use of in vivo and in vitro tests to evaluate toxicity of chemical substances and drugs
Partim Hanson
This course describes the pharmacological basis of therapeutics. Each chapter begins with a short description of pathophysiology. Therapeutic targets and the drugs acting on them are highlighted. Novel directions in therapeutic strategy may also be described.
Learning outcomes of the learning unit
Partim Charlier
To evaluate toxicity of chemical substances and drugs, and before human use, several experimental steps must be done :
- micro-organism tests : speed and cheap, but with a lot of disadvantages (cell wall, none micro-oranite, specificity of ADN repair mechansisms, etc...);
- eukaryotic cells tests : allow to control exactly the concentration used but not the study of influence of metabolic activation/inactivation (important in the study of cancer);
- in vivo tests : results more sensitive and easier to transpose to human; the choice of a species is the "key" choice ; it is determinated by taking into account metabolic process and detoxification mechanisms.
Partim Hanson
At the end of this course, the students are supposed:
- To know the main targets of drugs that are used in therapeutics, - To understand why it is interesting to act on such targets, - To be able to give a few examples of drugs that are used clinically, - To describe innovative strategies for the discovery of new drugs.
Prerequisite knowledge and skills
Having had success in "Toxicological precepts" of the former academic year
Notions of general pharmacology, physiology and pathophysiology.
Planned learning activities and teaching methods
Not appliable
Mode of delivery (face to face, distance learning, hybrid learning)
Partim Charlier & Hanson
Ex-cathaedra or on line
Recommended or required readings
...
Exam(s) in session
Any session
- In-person
written exam
- Remote
written exam
Additional information:
Partim Charlier
QCM with some short open questions, in june
Partim Hanson
QCM face to face or on E-campus in june
Work placement(s)
Organisational remarks and main changes to the course
Partim CHARLIER : teaching by CHARLIER C and DEVILLE M
Contacts
Professeur Corinne CHARLIER
Clinical,Forensic and Environmental Toxicological laboratory
CHU B35
Sart-Tilman, B4000 Liège
Tél.04/3237683
Fax 04/3238889
e-mail : C.Charlier@chuliege.be
Dr. Julien Hanson
Laboratoire de Pharmacologie Moléculaire
CHU, B34, +4
Sart-Tilman, B4000 Liège
Tel: 04/3664748
e-mail: j.hanson@uliege.be