Duration
15h Th
Number of credits
| Master in bio-informatics and modelling (120 ECTS) | 2 crédits | |||
| Master in biochemistry and molecular and cell biology (120 ECTS) | 2 crédits |
Lecturer
N...
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
SECTION I: Approaches to the study of bacterial pathogenesis
- Microbes and disease: establishing a connection
- Models for studying bacterial pathogenesis
- Strategies for identifying bacterial pathogenicity genes
- Genetics determinants of bacterial pathogenicity
- Fimbrial adhesins: adhesive molecules on a "stalk"
- Non-pilus (non fimbrial) adhesins
- Biofilms: the story of microbial communities
SECTION III: Poisoning the host by toxins
- Toxins damaging cellular membranes: paradigms and molecular features
- Toxins acting on intracellular targets
SECTION IV: Cellular invasion by bacterial pathogens
- Mechanism of bacterial entry into host cells
- The bacterial life in a vacuole
- The bacterial life in the cytosol
SECTION V: Bacterial evasion of host defences
- Bacterial handling of host nutrients: the iron paradigm
- Bacterial escape from the complement system
- Bacterial resistance to antimicrobial peptides
- Bacteria-induced host cell death
SECTION VI : Specific bacterial pathogens
- Staphylococcus aureus: many types of staphylococcal infection
- Escherichia coli : lmany types of infecton
- Streptococcus pneumoniae
- Group A and Group B Streptococcus
- Pseudomonas aeruginosa
Learning outcomes of the learning unit
Successful completion of this course should enable students to:
- demonstrate broad knowledge of the cellular and molecular bases of bacterial host pathogen interactions;
- describe the principal mechanisms by which specific bacterial pathogens infect their hosts and cause disease.
Prerequisite knowledge and skills
Courses of general bacteriology and of bacterial physiology and genetics
Planned learning activities and teaching methods
Mode of delivery (face to face, distance learning, hybrid learning)
Face-to-face
Recommended or required readings
Reference book Bacterial Pathogenesis. A molecular approach Brenda A. Wilson, Abigail A. Salyers and Dixie D. Whitt, Malcom E. Winkler Third edtion ISBN 978-1-55581-418-2
Any session :
- In-person
oral exam
- Remote
oral exam
- If evaluation in "hybrid"
preferred in-person
Additional information:
Oral exam
Work placement(s)
Organisational remarks and main changes to the course
Contacts
Adresse ULiège : Bât. B6A Centre d'ingénierie des protéines Quartier Agora allée du six Août 11 4000 Liège 1 Belgique Tél. ULiège : +32 4 3669654 Fax ULiège : +32 4 3663364 Courriel : jddocquier@uliege.be