Duration
30h Th
Number of credits
| Bachelor in pharmacy | 4 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
Pharmaceutical analytical chemistry deals with the separation of matrix components, their identification and their quantitative determination. Quantitative analysis and measurements (or results) play a vital role in a number of industrial and research areas, include pharmacy and other sciences. Many analysts spend a considerable amount of their time collecting quantitative information from often very complex matrices. Consequently, analytical chemistry is a very important tool for investigative research in a number of areas (chemical, biomedical, pharmaceutical...). Pharmaceutical analytical chemistry therefore forms a core teaching unit in the Bachelor level in Pharmaceutical Sciences. It is based on the life cycle of analytical procedures, i.e. the resolution of problems covering the entire analytical life of the sample, from its origin to the final customer.
Clearly, all concepts intervening in the life cycle of an analytical procedure cannot be addressed in this introduction to pharmaceutical analytical chemistry. The general analytical training of future pharmacists both in theoretical and practical terms, which be thus accomplished in the practical work in term Q4 (CHIM0321-1) and the course in term Q5.
The objectives of the introductory course in pharmaceutical analytical chemistry can therefore be summarized as follows:
To give to the students the theoretical basis necessary for the analysis of active ingredients used in pharmaceutical field. - Analytical Procedure (Life Cycle); - Understanding and presentation of results; - Types of error; - Expression of concentration levels (reminder).
To provide relevant information on the following techniques: - Titrimetry (acid-base titration, complexometric titration, redox titration, etc.) - Electroanalysis (Potentiometry, Amperometry, Conductimetry) - Electronic spectroscopy: Ultraviolet and visible absorption spectroscopy, atomic absorption and flame emission spectroscopy and fluorescence spectroscopy - Vibrational Spectroscopy: Mid-infrared spectroscopy, near-infrared spectroscopy and Raman - Hyperspectral imaging - Introduction to mass spectrometry - Falsified medicines
Learning outcomes of the learning unit
To introduce the theoretical concepts necessary for the analysis of pharmaceutical active ingredients such as the expression of concentrations, the presentation of results and the types of errors. To address the various technical aspects of titrimetric, electrochemical and spectroscopic methods. To enable the future pharmacists to adopt an analytical approach to work.
Prerequisite knowledge and skills
- General Chemistry (courses for biomedical and pharmaceutical students).
- Physical and mathematical bases of biomedical sciences.
Planned learning activities and teaching methods
Practical exercises will take place independently of theoretical teaching (Practical exercises - Introduction to Pharmaceutical Analytical Chemistry, 100h - CHIM0321-3).
Mode of delivery (face to face, distance learning, hybrid learning)
Face-to-face or distance learning according to the health recommendations related to COVID-19. Lectures are ex-cathedra. Short video sequences and demonstrations will illustrate the theoretical concepts and their understanding will be directly evaluated using the interactive Wooclap platform. Lectures during Q4.
Recommended or required readings
Condensed notes and PowerPoint slides are available on the eCampus platform.
General works (Recommended readings): "Chimie analytique"; Skoog, West, Holler, Crouch (French edition, 3rd edition) Ed. De Boeck, 2015. "Analyse Chimique. Méthodes et techniques instrumentales modernes" (9th edition); Rouessac, Ed. Dunod, 2019. "Analytical Chemistry", Christian, Dasgupta, Schug (7th Edition) Ed. Wiley, 2013.
Exam(s) in session
Any session
- In-person
written exam AND oral exam
- Remote
written exam AND oral exam
Additional information:
Exam using eCampus platform on the subject defined by the Professor and scientific staff.
Work placement(s)
Internship opportunity.
Student assistant: opportunities are given to students interested in teaching Pharmaceutical Analytical Chemistry. The work mainly consists of supervising practical exercises.
Research: outside class and exam periods (from the end of the second year of the Bachelor in Pharmaceutical Sciences), students interested in Pharmaceutical Analytical Chemistry can participate in an internship in the laboratory (student-researchers). PhD degrees can subsequently be prepared in the laboratory.
Organisational remarks and main changes to the course
The assistants are available to answer to the questions of the students, but they have to take an appointement by email.
Contacts
Philippe Hubert, Laboratory of Pharmaceutical Analytical Chemistry, CIRM, Department of Pharmacy, CHU Bât. B36 (+2), Quartier Hôpital, avenue Hippocrate 15, 4000 Liège
Phone. : 04/366.43.16
e-mail: ph.hubert@uliege.be
Eric Ziemons
Phone: +32 4 366.98.01
e-mail: eziemons@uliege.be
Charlotte De Bleye
Phone: +32 4 366.43.24
e-mail: cdebleye@uliege.be
Hugues Jambo
Phone: +32 4 366.43.19
e-mail: hjambo@uliege.be
Sébastien Lhoest
Phone: +32 4 366.43.23
e-mail: slhoest@uliege.be
Secretary :
Murielle Bihain
Phone: 04/366.43.16
e-mail: mbihain@uliege.be